Pharmaceutical Raw Steroid Powders Levonorgestrel CAS 797-63-7 for Progestin

Detailed Product Description

Pharmaceutical Raw Steroid Powders Levonorgestrel CAS 797-63-7 for Progestin

Levonorgestrel

Product Name: Levonorgestrel 
Synonyms: 13-ethyl-17-alpha-ethynyl-17-beta-hydroxy-4-gonen-3-one;13-ethyl-17-alpha-ethynylgon-4-en-17-beta-ol-3-one;13-ethyl-17-hydroxy-19-dinor-17-alpha-pregn-4-en-20-yn-3-on(+)-1;17-alpha-ethinyl-13-beta-ethyl-17-beta-hydroxy-4-estren-3-one;17-beta-hydroxy-18-methyl-19-nor-17-alpha-pregn-4-en-20-yn-3-one;17-ethynyl-18-methyl-19-nortestosteron;17-ethynyl-18-methyl-19-nortestosterone;18-methyl-17-alpha-ethynyl-19-nortestosterone 
CAS: 797-63-7 
MF: C21H28O2 
MW: 312.45 
EINECS: 212-349-8 

Chemical Properties White Solid 
Usage An emergency contraceptive. Levonorgestrel is safe, tolerated and effective in emergency contraception in woman 
Usage progestin

Levonorgestrel Usage: Levonorgestrel is used in emergency contraceptive pills(ECPs), both in a combined Yuzpe regimenwhich includes estrogen, and as a levonorgestrel-only method. The levonorgestrel-only method uses levonorgestrel 1.5mg (as a single dose or as two 0.75mg doses 12 hours apart) taken within 3 days of unprotected sex, with one study indicating that beginning as late as 120 hours (5 days) after intercourse could be effective.
The primary mechanism of action of levonorgestrel as a progestogen-only emergency contraceptive pill is, according to FIGO, to prevent fertilization by inhibition of ovulation. The International Federation of Gynecology and Obstetrics(FIGO) has issued a statement that: "review of the evidence suggests that LNG [levonorgestreol] ECPs cannot prevent implantation of a fertilized egg. Language on implantation should not be included in LNG ECP product labeling." In June 2012, a New York Timeseditorial called on the Food and Drug Administration(FDA) to remove from the label the unsupported suggestion that levonorgestrel emergency contraceptive pills inhibit implantation. In November 2013, the European Medicines Agency(EMA) approved a change to the label for HRA Pharma's NorLevo saying it cannot prevent implantation of a fertilized egg. In November 2013, the EMA also approved a change to the label for HRA Pharma's NorLevo saying: "In clinical trials, contraceptive efficacy was reduced in women weighing 75 kg [165 pounds] or more, and levonorgestrel was not effective in women who weighed more than 80 kg [176 pounds]." In November 2013 and January 2014, the FDA and the EMA said they were reviewing whether increased weight and body mass index(BMI) reduce the efficacy of emergency contraceptives.

Levonorgestrel Specification:

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