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Home>Products>Raw Steroid Powders>CAS 288383-20-0 Pharmaceutical Chemicals Powder Cediranib / AZD2171

CAS 288383-20-0 Pharmaceutical Chemicals Powder Cediranib / AZD2171
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Pharmaceutical Chemicals Powder Cediranib / AZD2171 CAS 288383-20-0
1. Cediranib Description:
Name:Cediranib
Synonyms:AZD2171;4-(4-Fluoro-2-methylindol-5-yloxy)-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline;Recentin;Cediranib R
CAS:288383-20-0
MF:C25H27FN4O3
MW:450.51
Appearance: White crystalline solid
Assay:99%
Solubility:DMSO (10 mM)
Storage Temp.: -20°C
Shipping Conditions: RT
Handling: Protect from air and moisture
Description:Cediranib (AZD2171) s a potent inhibitor of vascular endothelial growth factor (VEGF) receptor tyrosine kinases.
Usage:Cediranib (AZD2171) inhibited VEGF-stimulated proliferation and KDR phosphorylation with IC50 of 0.4 and 0.5 nM, respectively.
Packing:1g/foil bag
Packing:foil bag or as required
2. Cediranib Usage:
Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration of AZD2171-an oral tyrosine kinase inhibitor of VEGF receptors-has rapid onset, is prolonged but reversible, and has the significant clinical benefit of alleviating edema. Reversal of normalization began by 28 days, though some features persisted for as long as four months. Basic FGF, SDF1alpha, and viable circulating endothelial cells (CECs) increased when tumors escaped treatment, and circulating progenitor cells (CPCs) increased when tumors progressed after drug interruption. Our study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor.
3. Cediranib Application:
Cediranib inhibition of bFGF and EGF when an IC50 of 0.5 and 0.11 μM. In the MG63 cell lines, Cediranib inhibiting PDGF-AA, IC50 of 0.04 μM. Cediranib Flt-1 associated kinase inhibition, IC50 of 5 nM, Cediranib inhibition of VEGF-C and VEGF-D receptor Flt-4, IC50 of less than 3 nM. [1] In addition, cediranib inhibition of c-Kit and PDGFR-β tyrosine kinase, IC50 were 2 and 5 nM. In vitro, micromolar concentrations cediranib can directly inhibit the proliferation of tumor cells. Sub nanomolar Cediranib blocking tubules produced, and inhibits VEGF-induced angiogenesis in vivo.
4. Our Advantages:
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